Motif ID: FOX{C1,C2}.p2

Z-value: 1.538


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXC1chr6_+_1610680-0.214.4e-01Click!
FOXC2chr16_+_86600856-0.185.0e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_64225496 8.878 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_74281884 8.469 ALB
albumin
chr3_+_133495925 8.299 TF
transferrin
chr10_+_7745341 7.313 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 6.839 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 6.678 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_149095333 6.595 TM4SF1
transmembrane 4 L six family member 1
chr10_+_7745284 6.285 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_149095413 6.196 TM4SF1
transmembrane 4 L six family member 1
chr14_+_95047758 6.149 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chrX_-_130423199 5.510 IGSF1
immunoglobulin superfamily, member 1
chr14_+_95047730 5.386 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr12_+_69742130 5.283 NM_000239
LYZ
lysozyme
chr12_+_69742140 5.123 LYZ
lysozyme
chr10_+_7745229 5.112 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_149095458 4.597 TM4SF1
transmembrane 4 L six family member 1
chr2_-_188419049 3.828 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr11_-_2156721 3.799 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_-_7082654 3.469 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr12_+_100867739 3.202 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr17_-_7082559 3.072 ASGR1
asialoglycoprotein receptor 1
chr3_-_114343791 3.018 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_189839132 2.452 COL3A1
collagen, type III, alpha 1
chr12_+_100867550 2.444 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr4_-_84035888 2.424 PLAC8
placenta-specific 8
chr2_+_189839113 2.422 COL3A1
collagen, type III, alpha 1
chr2_-_88427535 2.356 NM_001443
FABP1
fatty acid binding protein 1, liver
chr2_+_189839078 2.297 NM_000090
COL3A1
collagen, type III, alpha 1
chr4_-_100140330 2.180 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chrX_-_130423387 1.952 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr4_-_84035908 1.941 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr7_-_99573637 1.833 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr6_+_158438079 1.821 NM_001178088
SYNJ2
synaptojanin 2
chr17_-_39093671 1.806 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr21_-_43735462 1.765 TFF3
trefoil factor 3 (intestinal)
chr1_+_153600859 1.596 NM_006271
S100A1
S100 calcium binding protein A1
chr2_-_188419185 1.564 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr22_+_39916563 1.515 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr14_-_94855120 1.422 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94854910 1.421 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_+_95047792 1.348 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_-_114790221 1.345 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_82068958 1.314 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_216300444 1.269 FN1
fibronectin 1
chr19_+_8509875 1.267 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr9_+_124048396 1.259 GSN
gelsolin
chr3_-_149095517 1.142 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr7_+_94285736 1.091 PEG10
paternally expressed 10
chr7_+_134832765 1.069 NM_018295
TMEM140
transmembrane protein 140
chr14_+_100531764 1.012 EVL
Enah/Vasp-like
chr11_+_1860718 1.006 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr17_+_40714164 0.973 COASY
CoA synthase
chr7_-_50628744 0.966 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr14_+_100531745 0.966 NM_016337
EVL
Enah/Vasp-like
chr16_+_69680959 0.965 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr21_-_43735705 0.940 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr21_-_43816123 0.892 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr9_-_115480363 0.869 NM_021218
C9orf80
chromosome 9 open reading frame 80
chr17_-_39092714 0.845 KRT23
keratin 23 (histone deacetylase inducible)
chr17_+_48821106 0.836 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr9_-_131644176 0.835 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr17_+_40714091 0.809 NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233
COASY




CoA synthase




chr10_-_82049178 0.804 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_+_40714176 0.791 COASY
CoA synthase
chr15_-_90349819 0.780 ANPEP
alanyl (membrane) aminopeptidase
chr4_+_39063851 0.776 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr17_+_73472578 0.726 KIAA0195
KIAA0195
chr5_+_35856990 0.692 NM_002185
IL7R
interleukin 7 receptor
chr7_+_26400503 0.615 NM_001199837
SNX10
sorting nexin 10
chr19_-_43031343 0.612 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr7_+_94285676 0.605 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr11_-_8832881 0.597 NM_139157
ST5
suppression of tumorigenicity 5
chr7_-_55930444 0.589 NM_207366
SEPT14
septin 14
chr8_-_17555158 0.577 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr14_+_76071804 0.569 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr10_-_7682741 0.568 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chrX_-_40506800 0.564 NM_144970
CXorf38
chromosome X open reading frame 38
chr1_-_36948423 0.562 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr2_-_190927321 0.561 NM_005259
MSTN
myostatin
chr16_+_69600110 0.544 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr4_+_3768295 0.544 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr6_-_138820580 0.542


chr2_+_69201704 0.528 NM_019617
GKN1
gastrokine 1
chr8_-_11705259 0.517


chr10_-_7708805 0.513 NM_001001851
NM_030569
ITIH5

inter-alpha-trypsin inhibitor heavy chain family, member 5

chr6_-_133035180 0.512 NM_004666
VNN1
vanin 1
chr16_+_82068830 0.489 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr7_-_50633042 0.483 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr16_+_14927713 0.482 NOMO1
NODAL modulator 1
chr10_-_91102430 0.478 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr4_-_89978117 0.476 NM_014883
FAM13A
family with sequence similarity 13, member A
chr1_+_201979747 0.473 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr13_-_20346398 0.469 PSPC1
paraspeckle component 1
chr2_-_175260349 0.468 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr12_-_24103953 0.465 SOX5
SRY (sex determining region Y)-box 5
chr6_+_64356430 0.430 NM_015153
PHF3
PHD finger protein 3
chr21_-_27423423 0.423


chr9_+_124048869 0.420 GSN
gelsolin
chr3_-_93692592 0.410 PROS1
protein S (alpha)
chr10_-_98325100 0.410 TM9SF3
transmembrane 9 superfamily member 3
chr5_+_140474198 0.387 NM_018936
PCDHB2
protocadherin beta 2
chr10_+_90424145 0.381 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr2_+_161993465 0.373 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr2_+_27255837 0.371 TMEM214
transmembrane protein 214
chr9_+_134305476 0.366 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chrX_+_68835910 0.363 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr2_-_264037 0.363 NM_001159597
NM_015677
SH3YL1

SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

chr16_-_75467249 0.352 NM_006324
CFDP1
craniofacial development protein 1
chr17_-_47439326 0.351 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr6_+_87969619 0.351 ZNF292
zinc finger protein 292
chr19_+_7953380 0.351 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr6_+_155538096 0.345 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr16_-_72206023 0.345 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr7_+_102023016 0.336


chr20_+_57470200 0.335 GNAS
GNAS complex locus
chr9_-_136933091 0.319 NM_007371
BRD3
bromodomain containing 3
chr16_+_56995761 0.303 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr17_+_73452663 0.302 NM_014738
KIAA0195
KIAA0195
chr14_-_24777064 0.299


chr3_-_129599220 0.298 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr6_-_131291480 0.296 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_-_263982 0.294 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr22_+_20909221 0.288 MED15
mediator complex subunit 15
chr16_-_21222867 0.279 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr16_+_29831755 0.273 MVP
major vault protein
chr1_-_110933635 0.273 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chrX_-_40506666 0.268 CXorf38
chromosome X open reading frame 38
chr3_-_170303774 0.264 NM_020949
SLC7A14
solute carrier family 7 (orphan transporter), member 14
chr6_-_52710892 0.264 NM_153699
GSTA5
glutathione S-transferase alpha 5
chr3_-_13057130 0.264


chrX_-_24665225 0.260 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_36105005 0.259 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr17_+_26646120 0.256 NM_014573
TMEM97
transmembrane protein 97
chr5_-_32403310 0.253 ZFR
zinc finger RNA binding protein
chr10_-_112678902 0.249 NM_001195304
NM_001195305
NM_001195307
NM_001243783
BBIP1



BBSome interacting protein 1



chr5_+_71502700 0.245 MAP1B
microtubule-associated protein 1B
chr1_-_120612019 0.244 NOTCH2
notch 2
chr17_+_7623038 0.239 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr2_+_211458078 0.237 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr2_+_108905094 0.234 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr8_+_121457642 0.226 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr4_-_3534138 0.225 LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr1_+_244214552 0.224 NM_205768
ZNF238
zinc finger protein 238
chr1_-_110933683 0.213 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr11_+_118175294 0.213 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr1_+_67632168 0.212 NM_144701
IL23R
interleukin 23 receptor
chr22_+_18043147 0.209 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr12_-_111893857 0.205


chr13_+_52436116 0.205 NM_031290
CCDC70
coiled-coil domain containing 70
chr14_-_24553817 0.198 NM_006177
NRL
neural retina leucine zipper
chr16_+_29831714 0.198 NM_005115
NM_017458
MVP

major vault protein

chr17_-_3599298 0.194 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr3_-_47098906 0.192 SETD2
SET domain containing 2
chr5_+_176873795 0.186 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr1_-_231114580 0.184 TTC13
tetratricopeptide repeat domain 13
chr6_+_72926144 0.182 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_88285308 0.181 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_+_170366211 0.180 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr15_+_41056243 0.178 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr17_+_79373539 0.177 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr11_+_62009723 0.174 NM_006551
SCGB1D2
secretoglobin, family 1D, member 2
chr2_-_3523258 0.172 ADI1
acireductone dioxygenase 1
chr22_+_51176623 0.170 NM_001097
ACR
acrosin
chr1_-_203155910 0.166 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr15_+_80696569 0.159 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr16_-_53737713 0.158 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chrX_-_21776158 0.154 NM_014332
SMPX
small muscle protein, X-linked
chr5_+_156820161 0.150 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_-_57914287 0.148 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr16_+_4845265 0.147 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr1_+_46972667 0.143 NM_147192
NM_172225
DMBX1

diencephalon/mesencephalon homeobox 1

chr17_-_48945338 0.143 NM_001243877
TOB1
transducer of ERBB2, 1
chr1_+_244214576 0.140 ZNF238
zinc finger protein 238
chr16_-_29937523 0.140 KCTD13
potassium channel tetramerisation domain containing 13
chr14_+_74815194 0.135 VRTN
vertebrae development homolog (pig)
chr1_+_27719151 0.135 NM_005281
GPR3
G protein-coupled receptor 3
chr17_-_67311773 0.135 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr17_-_7137580 0.133 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr4_+_120056938 0.133 NM_016599
MYOZ2
myozenin 2
chr4_-_48136245 0.127 NM_003328
TXK
TXK tyrosine kinase
chr3_+_132036210 0.123 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr3_-_194090459 0.122 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr17_+_7461591 0.120 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr9_+_32384622 0.120 ACO1
aconitase 1, soluble
chr17_-_3599359 0.119 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr1_-_203155813 0.119 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_-_20622433 0.113 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr20_+_9198036 0.112 NM_182797
PLCB4
phospholipase C, beta 4
chrX_-_33146543 0.111 NM_004010
NM_004009
DMD

dystrophin

chr1_+_152691997 0.109 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr11_+_111783459 0.109 NM_001541
HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr7_-_44924946 0.107 NM_033224
PURB
purine-rich element binding protein B
chr3_+_132036276 0.106 ACPP
acid phosphatase, prostate
chr20_+_42143045 0.103 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr11_-_64684606 0.102 NM_015104
ATG2A
ATG2 autophagy related 2 homolog A (S. cerevisiae)
chr4_+_26321307 0.102 NM_005349
NM_203283
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr11_-_62554790 0.102


chr17_+_58677603 0.101 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr1_-_203155827 0.098 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr2_-_174829108 0.096 SP3
Sp3 transcription factor

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
27.41 2.57e-03 GO:0010951 negative regulation of endopeptidase activity
6.36 1.71e-02 GO:0050817 coagulation
6.31 1.79e-02 GO:0007599 hemostasis
13.13 4.66e-02 GO:0051346 negative regulation of hydrolase activity
5.36 4.95e-02 GO:0042060 wound healing

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.06 3.32e-05 GO:0005576 extracellular region
10.68 5.15e-03 GO:0030141 stored secretory granule
7.80 5.39e-03 GO:0031012 extracellular matrix
4.15 1.06e-02 GO:0044421 extracellular region part
4.64 1.23e-02 GO:0005615 extracellular space
24.49 1.38e-02 GO:0031093 platelet alpha granule lumen
23.98 1.47e-02 GO:0034774 secretory granule lumen
23.03 1.66e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
22.14 1.86e-02 GO:0031983 vesicle lumen
7.85 2.17e-02 GO:0005578 proteinaceous extracellular matrix
20.56 2.32e-02 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
24.76 1.05e-03 GO:0004867 serine-type endopeptidase inhibitor activity
35.96 4.26e-03 GO:0005504 fatty acid binding
13.36 1.18e-02 GO:0030414 peptidase inhibitor activity
13.02 1.31e-02 GO:0061135 endopeptidase regulator activity
23.03 1.63e-02 GO:0033293 monocarboxylic acid binding
10.75 2.72e-02 GO:0061134 peptidase regulator activity